𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Epidermal growth factor receptor: Elements of intracellular communication

✍ Scribed by S. M. Teresa Hernández-Sotomayor; Graham Carpenter

Book ID
104674774
Publisher
Springer
Year
1992
Tongue
English
Weight
876 KB
Volume
128
Category
Article
ISSN
0022-2631

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✦ Synopsis

While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-gamma 1 are substrates for the EGF receptor tyrosine kinase has provided a beginning in understanding the biochemistry underlying growth factor receptor transduction.

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