𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Review of a promising new agent—pemetrexed disodium

✍ Scribed by Luis Paz-Ares; Susana Bezares; José M. Tabernero; Daniel Castellanos; Hernán Cortes-Funes

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
113 KB
Volume
97
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Pemetrexed disodium (ALIMTa, [pemetrexed], LY231514; Eli Lilly and Company; Indianapolis, IN), a novel antifolate antimetabolite with multiple enzyme targets involved in both pyrimidine and purine synthesis, has entered clinical trials due to its favorable pleclinical profile. Many studies utilizing the drug, as a single or combination agent, are currently ongoing, including Phase III trials in mesothelioma, nonsmall cell lung carcinoma (NSCLC) and pancreatic cancer. Promising feasibility and activity data have been obtained with pemetrexed in combination with platinum compounds and gemcitabine. The supplementation with daily oral folate could reduce the incidence of hematologic toxicities while preserving the antitumor activity of pemetrexed.

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