Review of a promising new agent—pemetrex
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Luis Paz-Ares; Susana Bezares; José M. Tabernero; Daniel Castellanos; Hernán Cor
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Article
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2003
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John Wiley and Sons
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English
⚖ 113 KB
Pemetrexed disodium (ALIMTa, [pemetrexed], LY231514; Eli Lilly and Company; Indianapolis, IN), a novel antifolate antimetabolite with multiple enzyme targets involved in both pyrimidine and purine synthesis, has entered clinical trials due to its favorable pleclinical profile. Many studies utilizing