Review: Nuclear Structure and DNA Replication
β Scribed by Melvin L. DePamphilis
- Book ID
- 115634083
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 250 KB
- Volume
- 129
- Category
- Article
- ISSN
- 1047-8477
No coin nor oath required. For personal study only.
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## Abstract The model of in situ DNA replication provided by immunofluorescence and confocal imaging is compared with observations obtained by electron microscopic studies. Discrepancies between both types of observations call into question the replication focus as a persistent nuclear structure an
## Abstract In higher eukaryotic cells, DNA is tandemly arranged into 10^4^ replicons that are replicated once per cell cycle during the S phase. To achieve this, DNA is organized into loops attached to the nuclear matrix. Each loop represents one individual replicon with the origin of replication