Reversion From Precore/Core Promoter Mutants to Wild-Type Hepatitis B Virus During the Course of Lamivudine Therapy
β Scribed by Sung Won Cho; Ki-Baik Hahm; Jin Hong Kim
- Book ID
- 111721208
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 234 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
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It has been reported that spontaneous or interferon (IFN)-induced hepatitis B e (HBe) seroconversion has usually been associated with the development of a stop codon in the precore region. However, the difference between lamivudine-induced seroconversion and spontaneous or IFN-induced seroconversion
## Abstract Adefovir dipivoxil (ADV) has demonstrated clinical activity against both wildβtype and lamivudineβresistant hepatitis B virus (HBV). We analyzed the evolution of viral load and the changes of polymerase and precore/core promoter sequences in lamivudineβresistant virus during ADV therapy
Hepatitis B virus (HBV) strains from anti-HBe positive patients often show specific mutations in the precore gene, the core promoter region, or both. The dynamics of seroconversion in relation to the appearance of these mutations has not been studied and compared between defined HBV genotypes. Sampl