Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy
β Scribed by Fumitaka Suzuki; Yoshiyuki Suzuki; Akihito Tsubota; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
- Book ID
- 118564789
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 103 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Adefovir dipivoxil (ADV) has demonstrated clinical activity against both wildβtype and lamivudineβresistant hepatitis B virus (HBV). We analyzed the evolution of viral load and the changes of polymerase and precore/core promoter sequences in lamivudineβresistant virus during ADV therapy
It has been reported that spontaneous or interferon (IFN)-induced hepatitis B e (HBe) seroconversion has usually been associated with the development of a stop codon in the precore region. However, the difference between lamivudine-induced seroconversion and spontaneous or IFN-induced seroconversion