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Reversing the multidrug resistance in acute leukemia: Until the leukemia initiating cell?

✍ Scribed by Régis T. Costello

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
81 KB
Volume
33
Category
Article
ISSN
0145-2126

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✦ Synopsis

Reversal of drug resistance is of pivotal importance in order to improve the results of chemotherapy. Monitoring of such reversal is necessary in order to analyze the results of clinical trials. Nonetheless, the leukemia cell population to eradicate is the leukemia initiating cells characterized by a CD34+CD38- phenotype. The evaluation of novel drug resistance modulators should be performed both in the whole leukemic cell population and in the leukemia initiating cell compartment, that is responsible for "mature" leukemia cells replenishment.

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