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Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance

✍ Scribed by Yasuo Kuwazuru; Akihiko Yoshimura; Shuichi Hanada; Atae Utsunomiya; Torahiko Makino; Kazuaki Ishibashi; Masahiko Kodama; Masato Iwahashi; Terukatsu Arima; Shin-Ichi Akiyama


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
616 KB
Volume
66
Category
Article
ISSN
0008-543X

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Using a DNA probe of mdrl and an anti-P-glycoprotein monoclonal antibody (MRK16), the authors investigated 19 cases of adult acute leukemia patients (one M1, six M2, three M3, one M4, three M5, two L1, and three L2), comparing leukemia cells at the initial presentation (I) with those at the relapsed