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Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas

✍ Scribed by Kenryu Nishiyama; Tsutomu Shirahama; Akihiko Yoshimura; Tomoyuki Sumizawa; Tatsuhiko Furukawa; Misako Ichikawa-Haraguchi; Shin-Ichi Akiyama; Yoshitada Ohi

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
842 KB
Volume
71
Category
Article
ISSN
0008-543X

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P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l