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Reversible site-selective labeling of membrane proteins in live cells

โœ Scribed by Guignet, Emmanuel G; Hovius, Ruud; Vogel, Horst

Book ID
109911186
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
382 KB
Volume
22
Category
Article
ISSN
1087-0156

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## Abstract **Click chemistry in vivo**: Three phosphatidic acid derivatives with alkyne groups in their fatty acid chains were synthesized and incorporated into mammalian cell membranes. Copper(I)โ€catalyzed and strainโ€promoted azideโ€“alkyne cycloaddition reactions were used for their visualization