Reversibility of the toxicity of methotrexate by dihydrofolate in mice
โ Scribed by F. Tzortzatou
- Book ID
- 108932867
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 152 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0305-1870
No coin nor oath required. For personal study only.
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We have previously demonstrated systemic resistance to methotrexate (MTX) in transgenic mice carrying a foreign, mutant dihydrofolate reductase (DHFR, E.C. 1 S.1.3) gene. The new gene was introduced as a cDNA cloned into an expression vector driven by the simian virus 40 (SV40) early promoter. Previ
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