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Expression of a methotrexate-resistant dihydrofolate reductase gene by transformed hematopoietic cells of mice

โœ Scribed by M. Bar-Eli; H. D. Stang; K. E. Mercola; M. J. Cline

Book ID
112559447
Publisher
Springer
Year
1983
Tongue
English
Weight
868 KB
Volume
9
Category
Article
ISSN
1572-9931

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๐Ÿ“œ SIMILAR VOLUMES

Expression of a methotrexate resistant d
Expression of a methotrexate resistant dihydrofolate reductase gene in transgenic mice
โœ Isola, Luis M. ;Gordon, Jon W. ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 750 KB

We have previously demonstrated systemic resistance to methotrexate (MTX) in transgenic mice carrying a foreign, mutant dihydrofolate reductase (DHFR, E.C. 1 S.1.3) gene. The new gene was introduced as a cDNA cloned into an expression vector driven by the simian virus 40 (SV40) early promoter. Previ