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Reversibility of monocytic differentiation of HL-60 cells by 1α,25 dihydroxyvitamin D3

✍ Scribed by Shigeru Tomoyasu; Kunihiko Fukuchi; Kazuyuki Watanabe; Hideyuki Ueno; Yasuharu Hamano; Jun-ich Hisatake; Ken-ichiro Hino; Kunihide Gomi; Nobuyoshi Tsuruoka

Book ID: 114119092
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 837 KB
Volume: 21
Category: Article
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(96)00112-9

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The effect of inhibitors of RNA synthesis on 1,25(OHI2 vitamin D3-induced monocytic differentiation was studied in a well-differentiating clone AB 47 of HL 60 cells. The concentrations of these inhibitors were chosen to permit the rnaintenance of cell viability for at least 48 hours, and resulted in