Activator protein-1 (AP-1) complex plays a central role in the regulation of both growth and differentiation in many cell types. Monocytic differentiation of HL-60 cells by TPA (1 2-O-tetradecanoyl phorbol-13-acetate) has been reported to be paralleled by increased AP-1 binding to DNA and by elevate
1,25-Dihydroxyvitamin D3promotes prostaglandin E1-induced differentiation of HL-60 cells
β Scribed by T. Kawase; S. Ogata; M. Orikasa; D. M. Burns
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 921 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1432-0827
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## Abstract Vitamin D derivatives have demonstrated antiβcancer activity, but their clinical use is precluded by hypercalcemia. Previously, we found that carnosic acid potentiates differentiation of human leukemia cells induced by low concentrations of 1alpha,25βdihydroxyvitamin D~3~ (1,25D~3~). In
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