Reversed-phase planar chromatography of some enantiomeric amino acids and oxazolidinones

✍ Scribed by L. Lepri; L. Boddi; M. Del Bubba; A. Cincinelli

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 87 KB
• Volume: 15
• Category: Article
• ISSN: 0269-3879
• DOI: 10.1002/bmc.61

✦ Synopsis

Abstract

The resolution of two enantiomeric amino acids and four structurally related oxazolidinones was evaluated by reversed‐phase planar chromatography using both home‐made microcrystalline cellulose triacetate (MCTA) layers and mobile phase additivies, such as β‐cyclodextrins (β‐Cy), modified α, β, γ cyclodextrins and bovine serum albumin (BSA), on commercially available RP‐18W/F~254~ and SilC~18–50~/UV~254~ plates. All the enantiomers were partially or baseline resolved by at least one of the chiral phases tested. Densitograms of optical antipodes and their mixtures were measured on MCTA layers developed with hydroalcoholic solvents. Copyright © 2001 John Wiley & Sons, Ltd.