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Reversed-phase high-performance liquid chromatographic separation of steroidal thiazoles

✍ Scribed by Pavel Drašar; Vladimír Pouzar; Ivan Černý; Miroslav Havel

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
225 KB
Volume
283
Category
Article
ISSN
1873-3778

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✦ Synopsis

Steroidal thiazoles of the 17/?-androstanyl-4-thiazole type are biologically and pharmaceutically important derivatives lw3. Members of this group show activities such as positive inotropic, cytotoxic and antimetabolic activity and inhibition activity ~3, NaK-ATPase.

In order to determine the residues of untransformed thiazoles in biological material we developed a high-performance liquid chromatographic method that allows the separation of these compounds and their determination, using UV-monitored Cl8 reversed-phase chromatography with a polar eluent.

EXPERIMENTAL

Apparatus and chromatography

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