Reversed MUC1/EMA polarity in both mucinous and micropapillary breast carcinoma—reply
✍ Scribed by Barbashina, Violetta; Corben, Adriana D.; Akram, Muzaffar; Vallejo, Christina; Tan, Lee K.
- Book ID
- 122284463
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 45 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1532-8392
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MUC1 mucin is a high molecular weight transmembrane glycoprotein expressed on the apical cell surface of normal glandular epithelia. In many human adenocarcinomas, this protein is up-regulated and/or underglycosylated, and its expression changes from apical to the entire cell membrane. It is thought
The cancer-associated epitope defined by the monoclonal antibody (MAb) 9H8 was shown to be closely related to the T antigen (Thornsen-Friedenreich antigen) by its sensitivity to 0-glycanase treatment of a mucin glycopeptide known to express this epitope. The reactivity with this glycopeptide increas