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Reversed BCRABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia

✍ Scribed by Dvorah Abeliovich; Orly Yehuda; Svetlana Krichevsky; Arnon Nagler; Susana Ben-Neriah; Marion Werner; Olga Ludkovsky; Dina Ben-Yehuda

Book ID: 113253446
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 269 KB
Volume: 81
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(94)00321-2

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## Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of __BCR‐ABL__ fusion mRNA with b2a2