Reverse Mannich reaction of some 5-hydro
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Monti, Stephen A.; Castillo, Gabriel D.
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Article
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1970
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American Chemical Society
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English
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The C4-dimethylaminomethyl Mannich adducts of 3-substituted 5-hydroxyindoles undergo a facile, amine catalyzed carbon-carbon bond cleavage to yield the corresponding Ca-hydrogen indole derivatives. Reverse Mannich condensation occurs most readily in Cs-carbethoxy substrates, then in ðyl derivativ