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Reverse-benzamidine antimalarial agents: Design, synthesis, and biological evaluation

✍ Scribed by Olivier Berger; Sharon Wein; Jean-Frederic Duckert; Marjorie Maynadier; Siham El Fangour; Roger Escale; Thierry Durand; Henri Vial; Yen Vo-Hoang

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
205 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.

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