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Reversal of α-difluoromethylornithine inhibition of caerulein-induced pancreatic growth by putrescine

✍ Scribed by Morisset, Jean; Benrezzak, Ouhida

Book ID
122913920
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
428 KB
Volume
11
Category
Article
ISSN
0167-0115

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Reversal of the growth inhibitory effect
Reversal of the growth inhibitory effect of α-difluoromethylornithine by putrescine but not by other divalent cations
✍ Stina M. Oredsson; Siw Anehus; Olle Heby 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 673 KB

Treatment with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor o