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Growth inhibition of a prostate tumor by α-difluoromethylornithine and by cyclophosphamide

✍ Scribed by Heston, Warren D.W.; Kadmon, Dov; Fair, William R.

Book ID
122495583
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
725 KB
Volume
16
Category
Article
ISSN
0304-3835

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A large body of evidence exists suggesting that polyamines can play essential roles in cellular growth and differentiation. We examined the ability of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the major rate-limiting enzyme in polyamine biosynthesis,