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Reversal of predominant enantioselectivity in the asymmetric alkynylation reaction using sulfamide-amine alcohols

✍ Scribed by Jincheng Mao; Zhanjin Zhang; Boshun Wan; Fan Wu; Shiwei Lu


Book ID
118171071
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
113 KB
Volume
7
Category
Article
ISSN
1566-7367

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Readily available sulfamide–amine alcoho
✍ Jincheng Mao; Boshun Wan; Fan Wu; Shiwei Lu πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 94 KB πŸ‘ 1 views

## Abstract Ephedrine‐derived sulfamide–amine alcohol **3** was found to be an effective catalyst for the asymmetric phenylacetylene addition to aldehydes at room temperature without using Ti(O^__i__^Pr)~4~ and Zn(OTf)~2~. It afforded the propargylic alcohols in high yields (up to 99%) and good ena