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Reversal of multidrug resistance by small interfering double-stranded RNAs in ovarian cancer cells

✍ Scribed by Tao Zhang; Ming Guan; Hong Yan Jin; Yuan Lu

Book ID
113959818
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
234 KB
Volume
97
Category
Article
ISSN
0090-8258

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## Abstract Breast cancer resistance protein (BCRP) is an ATP‐binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemothera