## Abstract Breast cancer resistance protein (BCRP) is an ATP‐binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemothera
✦ LIBER ✦
Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1
✍ Scribed by Yagüe, E; Higgins, C F; Raguz, S
- Book ID
- 110039560
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 159 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0969-7128
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We have established competitive reverse transcriptase polymerase chain reaction (RT-PCR) assay for the quantification of MDR1 mRNA encoding P-glycoprotein (P-gp) by analyzing leukemia sublines of MOLT-3 with various expression of MDR1. The expression was quantified by simultaneous RT-PCR of cellular