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Reversal of multidrug resistance by a liposome-MDR1 ribozyme complex

✍ Scribed by Yoshihiro Masuda; Hiroyuki Kobayashi; James F. Holland; Takao Ohnuma


Publisher
Springer
Year
1998
Tongue
English
Weight
886 KB
Volume
42
Category
Article
ISSN
0344-5704

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P-glycoprotein (Pgp)-conferred multidrug resistance (MDR) is expressed in cancer and in normal colon tissues and has important physiological functions. In order to selectively reverse MDR in malignant tissue without disrupting the function of normal colonocytes, a retroviral vector (pCEAMR) containi