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Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs

✍ Scribed by Marko Vezmar; Elias Georges


Book ID
113992254
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
482 KB
Volume
59
Category
Article
ISSN
0006-2952

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## We previously isolated agosterol A (AG -A) from a marine Spongia sp. and found that it completely reversed colchicine resistance in P-glycoprotein (Pgp)-over-expressing KB-C2 cells and vincristine resistance in multidrug-resistance protein (MRP)1-over-expressing CV60 cells. However, a tri-deacet