## Abstract For Abstract see ChemInform Abstract in Full Text.
Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp.
โ Scribed by DiGirolamo, Jessica A.; Li, Xing-Cong; Jacob, Melissa R.; Clark, Alice M.; Ferreira, Daneel
- Book ID
- 126891429
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 220 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0163-3864
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Five novel antimicrobial steroid sulfates, tqsentiastaol sulfates A-E (l-5) have been isolated from a marine sponge, Topsentio sp. Theii structures were elucidated to be 2.3.4, Ctetrahydroxy-M-methyl A%~I) sterol-2,3,6-trisulfates with unusual side chains. Topsentiasterol sulfates A-D have &de chain
Three new marine polar steroids, the first chlorine-containing steroid sulfate (1), topsentiasterol sulfate F (2) and the first natural iodinated steroid (3) have been isolated from the marine sponge Topsentia sp. The structures of 1-3 were elucidated using NMR and HRESIMS as well as by chemical cor