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Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells

✍ Scribed by Francesco Bertolini; Lucia De Monte; Chiara Corsini; Lorenza Lazzari; Eleonora Lauri; Davide Soligo; Maureen Ward; Arthur Bank; Fabio Malavasi


Book ID
114713814
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
745 KB
Volume
88
Category
Article
ISSN
0007-1048

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Retrovirus-mediated transfer of anti-MRD
✍ Hiroyuki Kobayashi; Yuzuru Takemura; Fu-Sheng Wang; Tetsuo Oka; Takao Ohnuma πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 136 KB

One of the underlying mechanisms of multidrug resistance (MDR) is cellular over-production of P-glycoprotein (P-gp), which acts as a drug efflux pump. P-gp is encoded by a small group of related genes termed MDR; only MDR1 is known to confer drug resistance. To overcome P-gp-mediated drug resistance