✦ LIBER ✦

Retroviral vectors for persistent expression in vivo

✍ Scribed by Robert K. Naviaux; Inder M. Verma

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 758 KB
Volume: 3
Category: Article
ISSN: 0958-1669
DOI: 10.1016/0958-1669(92)90083-u

No coin nor oath required. For personal study only.

✦ Synopsis

Retroviral vectors provide a safe and efficient method of introducing genes of therapeutic interest into dividing cells. The principle limitation of these vectors in the past has been poor gene expression in vivo. This problem has been overcome recently through the use of tissue-specific enhancers in commonly used retroviral vectors. In this review we discuss both the relevant biology and some of the practical applications of retroviral vectors in gene therapy.

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