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Retrotransposons and the evolution of mammalian gene expression

โœ Scribed by D. M. Robins; L. C. Samuelson

Publisher
Springer Netherlands
Year
1992
Tongue
English
Weight
979 KB
Volume
86
Category
Article
ISSN
0016-6707

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โœฆ Synopsis

Transposable elements, and retroviral-like elements in particular, are a rich potential source of genetic variation within a host's genome. Many mutations of endogenous genes in phylogenetically diverse organisms are due to insertion of elements that affect gene expression by altering the normal pattern of regulation. While few such associations are known to have been maintained over time, two recently elucidated examples suggest transposable elements may have a significant impact in evolution of gene expression. The first example, concerning the mouse sex-limited protein (Slp), clearly establishes that ancient retroviral enhancer sequences now confer hormonal dependence on the adjacent gene. The second example shows that within the human amylase gene family, salivary specific expression has arisen due to inserted sequences, deriving perhaps from a conjunction of two retrotransposable elements.

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