Retrograde neurotrophin signaling: Trk-ing along the axon
β Scribed by David D Ginty; Rosalind A Segal
- Book ID
- 114313891
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 77 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0959-4388
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## Abstract JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to KinesinβI, a major molecular motor for axonal transport. Recent research sheds further light on JIPs' complex roles in axonal transport, namely in activation of Ki
Neurons of both the central and the peripheral nervous system are critically dependent on neurotrophic signals for their survival and differentiation. The trophic signal is originated at the axonal terminals that innervate the target(s). It has been well established that the signal must be retrograd