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Retro-aldol cleavage of bafilomycin derivatives

✍ Scribed by Kenneth L. Granberg; Karin M. Edvinsson; Kristina Nilsson

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 225 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02365-x

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✦ Synopsis

The intermediates 3 and 4, useful in the preparation of new biologically active bafilomycin derivatives, were obtained via a thermal retro-aldol reaction in diphenyl ether. The starting materials 5 and 7 for the retro-aldol reaction were synthesized in a few steps from bafilomycin C~ (2) with or without a protective group at 7-OH.

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