𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Retinoids in biological control and cancer

✍ Scribed by Anthonise Louis Fields; Dianne Robert Soprano; Kenneth J. Soprano

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
249 KB
Volume
102
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

More than 80 years ago, Wolbach and Howe provided the first evidence suggesting a link between alterations within human cells that lead to malignancies and vitamin A deficiencies (Wolbach and Howe 1925 Nutr. Rev. 36: 16–19). Since that time, epidemiological, preclinical and clinical studies have established a causative relationship between vitamin A deficiency and cancer. Laboratory research has provided insight into the intracellular targets, various signaling cascades and physiological effects of the biologically‐active natural and synthetic derivatives of vitamin A, known as retinoids. Collectively, this body of research supports the concept of retinoids as chemopreventive and chemotherapeutic agents that can prevent epithelial cell tumorigenesis by directing the cells to either differentiate, growth arrest, or undergo apoptosis, thus preventing or reversing neoplasia. Continued refinement of the retinoid signaling pathway is essential to establishing their use as effective therapeutics for tumor subtypes whose oncogenic intracellular signaling pathways can be blocked or reversed by treatment with retinoids. J. Cell. Biochem. 102: 886–898, 2007. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Ets proteins in biological control and c
Ets proteins in biological control and cancer
✍ Tien Hsu; Maria Trojanowska; Dennis K. Watson 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

## Abstract The Ets family consists of a large number of evolutionarily conserved transcription factors, many of which have been implicated in tumor progression. Extensive studies on this family of proteins have focused so far mainly on the biochemical properties and cellular functions of individua

Retinoids and ovarian cancer
Retinoids and ovarian cancer
✍ Dongmei Zhang; William F. Holmes; Shujian Wu; Dianne R. Soprano; Kenneth J. Sopr 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 1 views

Each year, an estimated 26,000 women in the United States are diagnosed with ovarian cancer. During any given year, approximately 14,500 women die from this disease. Ovarian cancer is the seventh most common cancer in women worldwide, after breast, cervix, colon/rectum, stomach, corpus uteri, and lu

β-Catenin signaling in biological contro
β-Catenin signaling in biological control and cancer
✍ Nancy Gavert; Avri Ben-Ze'ev 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB

## Abstract A coordinated integration of cell–cell adhesion and the control of gene expression is essential for the development of multicellular, differentiated organisms. β‐Catenin fulfils important regulatory functions in both cell–cell adhesion by linking cadherin adhesion receptors to the cytos

The hippo pathway in biological control
The hippo pathway in biological control and cancer development
✍ Siew Wee Chan; Chun Jye Lim; Liming Chen; Yaan Fun Chong; Caixia Huang; Haiwei S 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB

## Abstract The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase W

Genetic and epigenetic regulation in nuc
Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
✍ Gary S. Stein; Sayyed K. Zaidi; Janet L. Stein; Jane B. Lian; Andre J. van Wijne 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB

## Abstract The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised wi

WWOX in biological control and tumorigen
WWOX in biological control and tumorigenesis
✍ Rami I. Aqeilan; Carlo M. Croce 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB

## Abstract The WW domain‐containing oxidoreductase (__WWOX__) gene is located at 16q23.1–16q23.2, a region that spans the second most common human fragile site, __FRA16D__. The WWOX protein contains two N‐terminal WW domains and a central short chain oxidoreductase‐like domain. In the last few yea