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Retinoic acid suppresses interleukin-6 synthesis induced by prostaglandins in osteoblasts

โœ Scribed by O. Kozawa; H. Tokuda; T. Kaida; H. Matsuno; T. Uematsu

Book ID
117642636
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
412 KB
Volume
58
Category
Article
ISSN
0952-3278

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Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts
โœ Haruhiko Tokuda; Osamu Kozawa; Atsushi Harada; Toshihiko Uematsu ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 80 KB

In osteoblast-like MC3T3-E1 cells, we have recently reported that sphingosine 1-phosphate among sphingomyelin metabolites acts as a second messenger for tumor necrosis factor-alpha (TNF)-induced interleukin-6 (IL-6) synthesis. In the present study, we investigated the effect of extracellular sphingo