Retinoic acid stimulates pyrophosphate elaboration by cartilage and chondrocytes
β Scribed by A. K. Rosenthal, L. A. Henry
- Book ID
- 120758411
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 991 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1432-0827
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π SIMILAR VOLUMES
The overproduction of inorganic pyrophosphate (PP,) by cartilage is thought to be a key element in the formation of calcium pyrophosphate dihydrate (CPPD) crystals in joints, and the subsequent development of pseudogout or chondrocalcinosis. We report herein that transforming growth factor Pl (TGFPl
SOX9 is a transcription factor that is expressed in chondrocytes and regulates expression of chondrocyte phenotype related genes. Expression of these genes is known to be suppressed by retinoic acid (RA). We, therefore, examined whether the Sox9 gene expression is regulated by RA in chondrocytes. RA