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Retinoic acid modulates the pattern of cell division in embryos ofLymnaea stagnalis(Mollusca)

✍ Scribed by Robbert Créton; Gideon Zwaan; René Dohmen

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
606 KB
Volume
204
Category
Article
ISSN
0949-944X

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✦ Synopsis

All-trans retinoic acid is well known as a modulator of positional specification in vertebrate development. A similar mechanism may operate in molluscan development. Molluscan development is characterized by an invariant pattern of cell divisions, which allows the study of individual cells in the developing organism. Low concentrations of exogenous retinoic acid applied during gastrulation affect the cell division pattern in the early larval stage of the mollusc Lymnaea stagnalis. A few cells from the apical plate, a larval organ consisting of seven large cleavage-arrested cells, were induced by retinoic acid to resume cell division. They typically formed an area of proliferating small cells that resembles the adjacent areas of precursor cells of adult ectoderm. The identification of individual cells that are transformed by retinoic acid may provide new insights into the mechanisms underlying positional specification within the embryo.

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