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Retinoic acid metabolites. 3. Total synthesis of (2E,4E,6E,8E)-3,7-dimethyl-9-[6,6-dimethyl-2-(hydroxymethyl)-1-cyclohexen-1-yl]-2,4,6,8-nonatetraenoic acid

✍ Scribed by Rosenberger, Michael; Neukom, Christian


Book ID
127079944
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
613 KB
Volume
47
Category
Article
ISSN
0022-3263

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Synthesis of 2E, 4E, 8E - nonatetraenoic
✍ Ute J. Haynes; J. E. Swigor πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 134 KB πŸ‘ 1 views

## Abstract The title compound 4‐(N‐acetylamino) phenyl‐1‐[^14^C] retinoate (3) was synthesized by a 2‐step sequence. Carboxyl‐[^14^C] vitamin A (1) was treated with ethylchloroformate to form the mixed anhydride (2). Treatment with acetamidophenol and heating with a catalytical amount of 4‐dimethy