Retinoic acid induces changes in Xenopus embryo glycolipid pattern

✍ Scribed by Angela M. Rizzo; Rosalba Gornati; Federica Rossi; Giovanni Bernardini; Bruno Berra

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 321 KB
• Volume: 19
• Category: Article
• ISSN: 1065-6995
• DOI: 10.1006/cbir.1995.1027

✦ Synopsis

Abstract

Retinoic acid (RA), known for its important role in cellular differentiation, may cause a modification of glycolipid distribution characterized by a shift from globoserie towards latto‐ and ganglio‐series. In the present paper, we have investigated the modifications of the lipidic pattern after exogenous RA treatment of Xenopus embryos. We have noticed a decrease in neutral glycolipids with a parallel increase in gangliosides; the content of sulfatides does not seem to be modified. Beside the shift toward ganglio‐serie, we have also observed a redistribution inside this class of lipids. In particular, following RA treatment, the relative distribution of GD1b and GT1b increases while that of GM3 decreases.