Reticulatacin: A new bioactive acetogenin from Annona reticulata (Annonaceae)

✍ Scribed by Johari M. Saad; Yu-hua Hui; J.Kent Rupprecht; Jon E. Anderson; John F. Kozlowski; Geng-xian Zhao; Karl V. Wood; Jeny L. McLaughlin

• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 482 KB
• Volume: 47
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)87082-4

✦ Synopsis

A new bioactive monoteuahydrofuraa acetogadn. reticulatacin, containing 37 carbons, has been isolated from a 95% EtOH e-xnact of the bark of A. reticulara by directing the fractionation with brine shrimp lethality. Another previously reported highly potent antitumor. adjacent ring bistetrahydrofuran acetogenin, bullatacin, has also been isolated in large quantity. Two known dikrpenes, (-)-kau-M-en-19-oic acid aad methyl 1@,17-dihydrt+(-)-kauran-19-oate and a known alkaloid, Modenine. have alao been isolated. Some of these compounds showed selective cytotoxic activities for certain human tumor cell lines.

carbons. This suggests that reticulatacin (1) and uvariamicin-II are different compounds. Furthermore, there was no bioactivity reported for the mixture of the uvariaxnicin compounds, and the bioactivities presented herein for pure reticulatacin (1) may help in differentiating these compounds in the future.