Ret in human development and oncogenesis
โ Scribed by Patrick Edery; Arnold Munnich; Stanislas Lyonnet; Charis Eng
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 821 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The development of a complex tissue from a few simple precursor cells requires the precise activation and repression of tissue-specific genes that determine cell lineages, tissue patterning, and cellular proliferation. In the kidney, a number of recently identified genes are critical for normal deve
## Abstract RET and NTRK1 are receptor tyrosine kinase (RTK) proteins which play a role in the development and maturation of specific component of the nervous system. Their alterations have been associated to several human diseases, including some forms of cancer and developmental abnormalities. Th
Signaling by GDNF through the Ret receptor is required for normal growth of the ureteric bud during kidney development. However, the precise role of GDNF/Ret signaling in renal branching morphogenesis and the specific responses of ureteric bud cells to GDNF remain unclear. Recent studies have provid