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Results of treatment of high risk childhood acute lymphoblastic leukemia

✍ Scribed by Kende, George ;El-Najjar, Khamis ;Ben-Bassat, Isaac ;Neuman, Yoram ;Ballin, Ami ;Ramot, Bracha

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 309 KB
Volume: 11
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950110111

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✦ Synopsis

Sixteen children with high risk acute lymphoblastic leukemia (ALL) who had one or more of the following risk factors: white cell count over 50 x 10g/liter, mediastinal mass, age under 2 or over 10 years, extramedullary involvement, or T-cell markers, were treated by a new protocol. All attained complete remission and 11 are still in their continuous Key words: high risk acute lymphoblastic leukemia (ALL), adenosine deaminase (ADA) first remission for 6-53 months. High activity of adenosine dearninase (ADA) in the leukemic cells seems to be an independent risk factor, as in the high ADA level group, 4 out of 7 patients relapsed and died, while none of the 8 patients with low ADA levels relapsed or died.

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