𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia

✍ Scribed by Helen D. Bailey; Bruce K. Armstrong; Nicholas H. de Klerk; Lin Fritschi; John Attia; Rodney J. Scott; Elizabeth Smibert; Elizabeth Milne; for the Aus-ALL Consortium

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
282 KB
Volume
129
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Previous studies suggest that exposure to pesticides increases the risk of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether professional pest treatments in or around the home before birth or during childhood increased the risk of childhood ALL. Data from 388 cases and 870 frequency‐matched controls were analyzed using unconditional logistic regression, adjusting for study matching variables and potential confounders, to calculate odds ratios (ORs). A meta‐analysis of our findings with the published findings of previous studies was also conducted. The ORs for any professional pest control treatments were 1.19 (95% CI 0.83, 1.69) in the year before pregnancy, 1.30 (95% CI 0.86, 1.97) during pregnancy and 1.24 (95% CI 0.93, 1.65) for those done after the child's birth. The ORs for exposure after birth were highest when it occurred between the ages of two and three years. ORs were elevated for termite treatments before birth. ORs were higher for pre‐B than T cell ALL and for t(12;21) (ETV6‐Runx‐1) than other cytogenetic sub‐types. The pooled OR from a meta‐analysis of our study with three previous studies of professional pest control treatments during pregnancy was 1.37 (95% CI 1.00, 1.88). Our results, and those of our meta‐analysis, provide some evidence of a modestly increased risk of ALL for professional pest control treatments done during the index pregnancy and possibly in the child's early years. The analysis of pooled data from international collaborations may provide more certainty regarding these potentially important associations.

📜 SIMILAR VOLUMES

Exposure to house painting and the use o
Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia
✍ Helen D. Bailey; Elizabeth Milne; Nicholas H. de Klerk; Lin Fritschi; John Attia 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB

## Abstract Painting in the home has been identified as a potential risk factor for childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether exposure to house painting or floor treatments before birth or during childhood increased the risk of childhood ALL.

Early life exposure to infections and ri
Early life exposure to infections and risk of childhood acute lymphoblastic leukemia
✍ Kevin Y. Urayama; Xiaomei Ma; Steve Selvin; Catherine Metayer; Anand P. Chokkali 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB

## Abstract Evidence from a growing number of studies indicates that exposure to common infections early in life may be protective against childhood acute lymphoblastic leukemia (ALL). We examined the relationship between three measures of early life exposure to infections—daycare attendance, birth

Improvement in CNS protective treatment
Improvement in CNS protective treatment in non-high-risk childhood acute lymphoblastic leukemia: report from the Japanese Children's Cancer and Leukemia Study Group
✍ Tsurusawa, Masahito; Katano, Naoyuki; Yamamoto, Yoshifumi; Hirota, Takahisa; Koi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 3 views

Background. Prevention of central nervous system (CNS) leukemia by early introduction of therapy to this sanctuary site is an essential component of modern treatment strategy for acute lymphoblastic leukemia (ALL). However, the optimal form of preventive CNS therapy remains debatable. Procedure. To

Role of NQO1, MPO and CYP2E1 genetic pol
Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
✍ Maja Krajinovic; Hugues Sinnett; Chantal Richer; Damian Labuda; Daniel Sinnett 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB

## Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobac