In murine myocarditis, it has been shown that natural killer cells first infiltrate the heart, followed by activated T-cells, which play an important role in the pathogenesis of the myocardial damage. In the same model of acute myocarditis, the repertoire of T-cell receptor (TCR) V p genes in infilt
โฆ LIBER โฆ
Restricted usage of T-cell receptor V beta genes and expression of perforin in infiltrating T cells in murine hearts with acute myocarditis caused by Coxsackievirus B3
โ Scribed by Yoshinori Seko; Tsutomu Yamazaki; Hideo Yagita; Ko Okumura; Ryozo Nagai; Yoshio Yazaki
- Book ID
- 115983919
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 107 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2828
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Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of the myocardial cell damage involved in viral myocarditis. Using a murine model of acute myocarditis caused by Coxsackievirus B3 (CVB3), perforin-expressing killer cells have been shown to infiltrate the heart, and interce