✦ LIBER ✦

EXPRESSION OF VASCULAR CELL ADHESION MOLECULE-1 IN MURINE HEARTS WITH ACUTE MYOCARDITIS CAUSED BY COXSACKIEVIRUS B3

✍ Scribed by SEKO, YOSHINORI; YAGITA, HIDEO; OKUMURA, KO; YAZAKI, YOSHIO

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 582 KB
Volume: 180
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199612)180:4<450::aid-path693>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of the myocardial cell damage involved in viral myocarditis. Using a murine model of acute myocarditis caused by Coxsackievirus B3 (CVB3), perforin-expressing killer cells have been shown to infiltrate the heart, and intercellular adhesion molecular-1 (ICAM-1) together with major histocompatibility complex (MHC) antigen was induced on myocardial cells in acute viral myocarditis. To clarify the immunological mechanisms in more detail, the expression of vascular cell adhesion molecular-1 (VCAM-1) has been examined in the heart of acute myocarditis and on cultured cardiac myocytes treated with interferon-gamma (TFN-y) and tumour necrosis factor-alpha (TNF-a). The effects of in vivo antibody treatment to VCAM-I on myocardial damage involved in acute myocarditis were also analysed. CVB3-induced myocarditis resulted in enhanced expression of VCAM-1 on myocardial cells. VCAM-1 expression was also induced on cultured cardiac myocytes by treatment with IFN-;J and TNF-a. The in viva antibody treatment to VCAM-1 decreased the myocardial damage to some extent, but the effects were not statistically significant. These data suggest that the expression of VCAM-1 on myocardial cells may play at least a partial role in the myocardial damage involved in acute viral myocarditis.

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