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Restricted Conformation Analogues of an Anthelmintic Cyclodepsipeptide

✍ Scribed by Dutton, Fred E.; Lee, Byung H.; Johnson, Sandra S.; Coscarelli, Eileen M.; Lee, Pil H.


Book ID
115314178
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
329 KB
Volume
46
Category
Article
ISSN
0022-2623

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Synthesis, conformational studies and an
✍ Scherkenbeck, JΓΌrgen; Dyker, Hubert; Gondol, Daniel; Harder, Achim; Plant, Andre πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 179 KB πŸ‘ 2 views

A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF1022A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the conΓΌrmation of this analogue is both rigidiΓΌed and distorted compared with the asymmetric conformation of PF1022A