## Abstract Several recently discovered marine products have remarkable in vitro and in vivo anticancer profiles against a wide range of tumor cell lines. Some of these compounds are currently in clinical trials. These compounds show complex structures and mechanisms of action of interest. Herein,
Synthesis, Conformational Analysis, and Cytotoxicity of New Analogues of the Natural Cyclodepsipeptide Jaspamide †
✍ Scribed by Terracciano, Stefania; Bruno, Ines; Bifulco, Giuseppe; Copper, Jean E.; Smith, Charles D.; Gomez-Paloma, Luigi; Riccio, Raffaele
- Book ID
- 127091115
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 143 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0163-3864
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## Abstract Starting with the ω‐hydroxy and ω‐amino acid derivatives **13** and **21**, the two closely related geodiamolide analogs **32** and **35**, respectively, were prepared. Compared to the natural cyclodepsipeptide geodiamolide (**1**), the macrocycles **32** and **35** have a smaller ring
By replacing two cysteine residues in apamin with selenocysteine, the three possible isomers related to the side-chain connectivities of a bis-cystinyl-peptide were synthesized in regioselective manner exploiting the low redox potential of the diselenide bond. Nuclear magnetic resonance conformation