Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
✍ Scribed by Aguilar-Lemarroy, Adriana; Gariglio, Patricio; Whitaker, Noel J; Eichhorst, Sören T; Hausen, Harald zur; Krammer, Peter H; Rösl, Frank
- Book ID
- 110066210
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 442 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs