𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Resting-state functional connectivity of the rat brain

✍ Scribed by Christopher P. Pawela; Bharat B. Biswal; Younghoon R. Cho; Dennis S. Kao; Rupeng Li; Seth R. Jones; Marie L. Schulte; Hani S. Matloub; Anthony G. Hudetz; James S. Hyde

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
905 KB
Volume
59
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Regional‐specific average time courses of spontaneous fluctuations in blood oxygen level dependent (BOLD) MRI contrast at 9.4T in lightly anesthetized resting rat brain are formed, and correlation coefficients between time course pairs are interpreted as measures of connectivity. A hierarchy of regional pairwise correlation coefficients (RPCCs) is observed, with the highest values found in the thalamus and cortex, both intra‐ and interhemisphere, and lower values between the cortex and thalamus. Independent sensory networks are distinguished by two methods: data driven, where task activation defines regions of interest (ROI), and hypothesis driven, where regions are defined by the rat histological atlas. Success in these studies is attributed in part to the use of medetomidine hydrochloride (Domitor) for anesthesia. Consistent results in two different rat‐brain systems, the sensorimotor and visual, strongly support the hypothesis that resting‐state BOLD fluctuations are conserved across mammalian species and can be used to map brain systems. Magn Reson Med 59:1021–1029, 2008. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Disease state prediction from resting st
Disease state prediction from resting state functional connectivity
✍ R. Cameron Craddock; Paul E. Holtzheimer III; Xiaoping P. Hu; Helen S. Mayberg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 935 KB

## Abstract The application of multivoxel pattern analysis methods has attracted increasing attention, particularly for brain state prediction and real‐time functional MRI applications. Support vector classification is the most popular of these techniques, owing to reports that it has better predic

Modulation of functional connectivity du
Modulation of functional connectivity during the resting state and the motor task
✍ Tianzi Jiang; Yong He; Yufeng Zang; Xuchu Weng 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

## Abstract Quite a few studies in functional magnetic resonance imaging (fMRI) have tested that, even in a resting state, motor cortices constitute a network. It has never been investigated how the network modulates from the resting state to the motor task state. In this report, by a newly develop

Hierarchical functional modularity in th
Hierarchical functional modularity in the resting-state human brain
✍ Luca Ferrarini; Ilya M. Veer; Evelinda Baerends; Marie-José van Tol; Remco J. Re 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 728 KB

## Abstract Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in the brain functional connectivity (BFC) map have highlighted the BFC's small‐world topology. Modu

Heritability of “small-world” networks i
Heritability of “small-world” networks in the brain: A graph theoretical analysis of resting-state EEG functional connectivity
✍ Dirk J. A. Smit; Cornelis J. Stam; Danielle Posthuma; Dorret I. Boomsma; Eco J. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB 👁 1 views

## Abstract Recent studies have shown that resting‐state functional networks as studied with fMRI, EEG, and MEG may be so‐called small‐world networks. We investigated to what extent the characteristic features of small‐world networks are genetically determined. To represent functional connectivity

Functional connectivity of cortical moto
Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
✍ Tao Wu; Xiangyu Long; Liang Wang; Mark Hallett; Yufeng Zang; Kuncheng Li; Piu Ch 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 556 KB

## Abstract Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current stud