Modulation of functional connectivity during the resting state and the motor task

✍ Scribed by Tianzi Jiang; Yong He; Yufeng Zang; Xuchu Weng

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 338 KB
• Volume: 22
• Category: Article
• ISSN: 1065-9471
• DOI: 10.1002/hbm.20012

✦ Synopsis

Abstract

Quite a few studies in functional magnetic resonance imaging (fMRI) have tested that, even in a resting state, motor cortices constitute a network. It has never been investigated how the network modulates from the resting state to the motor task state. In this report, by a newly developed approach taking into account n‐to‐1 connectivity using 1‐to‐1 connectivity measures instead of conventional pairwise connectivity, we show the existence of a large organized functional connectivity network related to motor function in the resting brain with fMRI. More importantly, we found that such a network can be modulated from a conscious resting state to planning, initiation, coordination, guidance, and termination of voluntary movement state, exhibited by significant changes of functional connectivity of some brain regions in different brain activity. Moreover, a quantitative description of such a functional modulation has also been presented. Hum. Brain Mapp. 22:65–73, 2004. © 2004 Wiley‐Liss, Inc.